On this day in 1958…

The paper “Epigenetic Control Systems” by D.L. Nanney is published in the Proceedings of the National Academy of Sciences of the United States of America. In this paper, Nanney asks “Can any available operation, or combination of operations, yield an unambiguous. classification of cellular regulatory systems into genetic and epigenetic categories?” After cataloging the many … Continue reading On this day in 1958…

On this day in 1996…

The paper “Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation” by James Brownell, Jianxin Zhou, Tamara Ranalli, Ryuji Kobayashi, Diane Edmondson, Sharon Roth, and C. David Allis was published in Cell. This paper describes the identification for the first time of a specific protein that modifies the structure … Continue reading On this day in 1996…

On this day in 1959…

Arthur B. Pardee, Francois Jacob, and Jacques Monod submitted their paper “The Genetic Control and Cytoplasmic Expression of "Inducibility" in the Synthesis of β-galactosidase by E. Coli” to the Journal of Molecular Biology, which then published it in the June  1959 issue. This paper summarized two years of experiments identifying the abnormal regulation processes and … Continue reading On this day in 1959…

On this day in 1865…

Gregor Mendel presents his research results from his work on peas to the Nature Research Society of Brünn, initiating the modern genetics research program. In this presentation, Mendel introduces the concepts of dominant and recessive hereditary “factors.” Mendel also proposes two laws of heredity to explain his results, the Law of Segregation (that organisms inherit … Continue reading On this day in 1865…

On this day in 1975…

Science published the paper “DNA modification mechanisms and gene activity during development” by Robin Holliday and John Pugh. In this paper, Holliday and Pugh identify the place of 5-methyl-cytosine (5mC) in base pair transitions, proposing that this methylation could play an important role in the stability or instability of cell type differentiation through the switching … Continue reading On this day in 1975…