On this day in 1959…

Arthur B. Pardee, Francois Jacob, and Jacques Monod submitted their paper “The Genetic Control and Cytoplasmic Expression of “Inducibility” in the Synthesis of β-galactosidase by E. Coli” to the Journal of Molecular Biology, which then published it in the June  1959 issue. This paper summarized two years of experiments identifying the abnormal regulation processes and enzymes produced by mutated genes in E. Coli, supporting the hypothesis that some molecule—labelled later as messenger RNA (mRNA)—mediated the production of proteins from DNA.

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