Science published the paper “DNA modification mechanisms and gene activity during development” by Robin Holliday and John Pugh. In this paper, Holliday and Pugh identify the place of 5-methyl-cytosine (5mC) in base pair transitions, proposing that this methylation could play an important role in the stability or instability of cell type differentiation through the switching on and off of genes critical in development. In their conclusion, Holliday and Pugh suggest their model could extend the Nobel prize-winning work of Barbara McClintock on the transposition of genetic elements.
Published by Shea Robison
I recently completed a postdoctoral research fellowship at the City University of Hong Kong in the Department of Public Policy with the Center for East Asian and Comparative Philosophy. I am now teaching courses in political science at Idaho State University and the College of Eastern Idaho. View all posts by Shea Robison